Weixia Zhong Selected Research

netupitant

6/2021	Central and peripheral emetic loci contribute to vomiting evoked by the Akt inhibitor MK-2206 in the least shrew model of emesis.
1/2021	The Contribution of Phospholipase C in Vomiting in the Least Shrew (Cryptotis Parva) Model of Emesis.
12/2019	Δ9-THC and related cannabinoids suppress substance P- induced neurokinin NK1-receptor-mediated vomiting via activation of cannabinoid CB1 receptor.
9/2018	Intracellular emetic signaling evoked by the L-type Ca2+ channel agonist FPL64176 in the least shrew (Cryptotis parva).
8/2017	The anti-asthmatic drug pranlukast suppresses the delayed-phase vomiting and reverses intracellular indices of emesis evoked by cisplatin in the least shrew (Cryptotis parva).
1/2017	Ca2+ signaling and emesis: Recent progress and new perspectives.
4/2016	Thapsigargin-induced activation of Ca(2+)-CaMKII-ERK in brainstem contributes to substance P release and induction of emesis in the least shrew.
4/2015	Differential and additive suppressive effects of 5-HT3 (palonosetron)- and NK1 (netupitant)-receptor antagonists on cisplatin-induced vomiting and ERK1/2, PKA and PKC activation.

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Weixia Zhong Research Topics

Disease

18	Vomiting 01/2023 - 01/2014
5	Nausea 01/2023 - 01/2017
5	Neoplasms (Cancer) 06/2021 - 01/2009
1	Diabetes Mellitus 04/2023
1	Virus Diseases (Viral Diseases) 01/2023
1	Bulimia (Binge Eating) 01/2023
1	Gallbladder Diseases (Gall Bladder Disease) 01/2023
1	Hyperphagia (Overeating) 01/2023
1	Motion Sickness (Airsickness) 01/2023
1	Body Weight (Weight, Body) 01/2022
1	Bacterial Infections (Bacterial Infection) 01/2017

Drug/Important Bio-Agent (IBA)

15	AntiemeticsIBA 01/2023 - 01/2014
11	EmeticsIBA 01/2023 - 04/2015
10	Palonosetron (Aloxi)FDA Link 06/2021 - 01/2014
8	Substance PIBA 01/2023 - 01/2014
8	netupitantIBA 06/2021 - 04/2015
8	Serotonin (5 Hydroxytryptamine)IBA 06/2021 - 01/2014
8	Cisplatin (Platino)FDA LinkGeneric 01/2020 - 01/2014
7	Nifedipine (Adalat)FDA LinkGeneric 06/2021 - 01/2014
6	5-HT3 Serotonin Receptors (5 HT3 Receptor)IBA 06/2021 - 01/2014
5	Dopamine (Intropin)FDA LinkGeneric 06/2021 - 01/2014
4	Dantrolene (Dantrium)FDA LinkGeneric 01/2021 - 01/2014
3	U 0126 (UO 126)IBA 06/2021 - 01/2021
3	Neurotransmitter Agents (Neurotransmitter)IBA 05/2021 - 01/2014
3	Neurokinin-1 Receptors (Neurokinin 1 Receptor)IBA 01/2021 - 04/2016
3	bisindolylmaleimide IIBA 01/2021 - 09/2018
3	CannabinoidsIBA 01/2020 - 01/2017
3	CalciumIBA 01/2017 - 01/2014
3	FPL 64176IBA 01/2017 - 01/2014
3	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 04/2016 - 01/2014
3	Amlodipine (Norvasc)FDA LinkGeneric 05/2015 - 01/2014
2	2- (4- morpholinyl)- 8- phenyl- 4H- 1- benzopyran- 4- oneIBA 01/2021 - 09/2018
2	Proteins (Proteins, Gene)FDA Link 01/2021 - 09/2012
2	QuinpiroleIBA 01/2021 - 05/2014
2	resiniferatoxinIBA 01/2020 - 01/2014
2	GR 73632IBA 12/2019 - 05/2014
2	CB1 Cannabinoid Receptor (CB1 Receptor)IBA 12/2019 - 01/2017
2	2- (2- amino- 3- methoxyphenyl)- 4H- 1- benzopyran- 4- oneIBA 09/2018 - 01/2014
2	ThapsigarginIBA 01/2017 - 04/2016
2	L-Type Calcium Channels (Dihydropyridine Receptor)IBA 05/2015 - 01/2014
2	LigandsIBA 09/2012 - 01/2009
1	Glucagon-Like Peptide 1 (GLP 1)IBA 04/2023
1	Opiate AlkaloidsIBA 01/2023
1	RNA (Ribonucleic Acid)IBA 01/2023
1	gastric inhibitory polypeptide receptorIBA 01/2022
1	Glucagon-Like Peptide-1 ReceptorIBA 01/2022
1	Peptide Hormones (Polypeptide Hormones)IBA 01/2022
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 06/2021
1	MK 2206IBA 06/2021
1	N- (4- methoxybenzyl)- N'- (5- nitro- 1,3- thiazol- 2- yl)ureaIBA 06/2021
1	SB 216763IBA 06/2021
1	perifosineIBA 06/2021
1	Glycogen Synthase Kinase 3IBA 06/2021
1	Protein Kinase CIBA 01/2021
1	Sulpiride (neogama)IBA 01/2021
1	Histamine (Histamine Dihydrochloride)FDA Link 01/2021
1	Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA 01/2021
1	Dopamine D2 Receptors (Dopamine D2 Receptor)IBA 01/2021
1	2,4,6- trimethyl- N- (meta- 3- trifluoromethylphenyl)benzenesulfonamideIBA 01/2021
1	mu Opioid Receptors (mu Opioid Receptor)IBA 01/2021
1	Type C PhospholipasesIBA 01/2021
1	1- (6- ((3- methoxyestra- 1,3,5(10)- trien- 17- yl)amino)hexyl)- 1H- pyrrole- 2,5- dioneIBA 01/2021
1	Copper Sulfate (Sulfate, Copper)FDA Link 01/2020
1	Dronabinol (THC)FDA LinkGeneric 01/2020
1	RimonabantIBA 12/2019
1	3- (2- hydroxy- 4- (1,1- dimethylheptyl)phenyl)- 4- (3- hydroxypropyl)cyclohexanolIBA 12/2019
1	CB2 Cannabinoid ReceptorIBA 12/2019
1	5-Hydroxytryptophan (5 Hydroxytryptophan)IBA 12/2019
1	pranlukastIBA 08/2017
1	LeukotrienesIBA 08/2017
1	Tropisetron (Navoban)IBA 08/2017
1	Anti-Asthmatic Agents (Antiasthmatic Drugs)IBA 08/2017
1	leukotriene D4 receptor (cysteinyl leukotriene receptor)IBA 08/2017
1	Sarcoplasmic Reticulum Calcium-Transporting ATPasesIBA 01/2017
1	palosentron drug combination netupitantIBA 01/2017
1	Cholinergic Agents (Cholinergics)IBA 01/2017
1	Serotonin ReceptorsIBA 04/2016
1	4- methyl- 4'- (3,5- bis(trifluoromethyl)- 1H- pyrazol- 1- yl)- 1,2,3- thiadiazole- 5- carboxanilideIBA 04/2016
1	Inositol (Myoinositol)IBA 04/2016
1	ProdrugsIBA 04/2016
1	RyanodineIBA 04/2016
1	Protein Kinases (Protein Kinase)IBA 04/2015
1	Phosphotransferases (Kinase)IBA 04/2015
1	Protein Kinase C-alphaIBA 04/2015
1	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 04/2015
1	TachykininsIBA 04/2015
1	(4- (m- Chlorophenylcarbamoyloxy)- 2- butynyl)trimethylammonium ChlorideIBA 05/2014
1	Apomorphine FDA Link 05/2014
1	Pilocarpine (Ocusert)FDA LinkGeneric 05/2014
1	Capsaicin (Zostrix)FDA Link 01/2014
1	Ruthenium RedIBA 01/2014
1	Viral ProteinsIBA 01/2014
1	capsazepineIBA 01/2014
1	Ion Channels (Ion Channel)IBA 01/2014
1	2-methyl-5-HTIBA 01/2014
1	Calcium-Calmodulin-Dependent Protein KinasesIBA 01/2014
1	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA 01/2014

Therapy/Procedure

3	Therapeutics 01/2021 - 01/2017
2	Drug Therapy (Chemotherapy) 09/2018 - 01/2017
1	Glycemic Control 01/2022